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. 2024 Aug 27;19(8):e0309245. doi: 10.1371/journal.pone.0309245

Fig 3. In vitro functional analysis of CARiC9-20/19 CAR-T cells.

Fig 3

(A-B) CAR-T cells derived from two healthy donors were assessed for cytotoxicity against Raji-GFP/Luc cells by Celigo image cytometry. Groups were compared by One-way ANOVA with Tukey multiple comparison, ***p < 0.001, **p < 0.01, *p < 0.05. (C) IFN-γ, (D) TNF-α, and (E) IL-2 secretion by CARiC9-20/19 CAR-T cells following antigen stimulation was determined by ELISA. Pan-T cells (non-modified cells) served as a control group. Data represent mean ± SD, n = 3. Groups were compared by Student’s t-test, ***p < 0.001. NS, not statistically significant.