Fig 4. Anti-tumor activity of CARiC9-20/19 CAR-T cells in a B-cell lymphoma immunodeficient xenograft mouse model.

(A) Schematic diagram of in vivo Raji xenograft model experimental design. (B-C) Bioluminescence imaging was performed to monitor tumor cell persistence (n = 4/group) and tumor growth were quantified by total flux (photon/s). (D) Kaplan-Meier survival curves for the different treatment groups are shown. **p < 0.01, *p < 0.05. NS, not statistically significant.