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. Author manuscript; available in PMC: 2024 Aug 27.

Published in final edited form as: Nat Neurosci. 2023 Nov 9;26(12):2090–2103. doi: 10.1038/s41593-023-01477-3

Extended Data Figure 5 — A. Representative single channel images from BrdU pulse-chase experiments in 2-month-old Patient^Corrected organoids. Images show the expression of the progenitor marker SOX2, the neuronal marker NeuN and the proliferative marker BrdU.

B. Representative single channel images from BrdU pulse-chase experiments in 2-month-old Patient^p.Q503X organoids. Images show the expression of the progenitor marker SOX2, the neuronal marker NeuN and the proliferative marker BrdU.

C. Representative single channel images from BrdU pulse-chase experiments in 2-month-old 03231^Control organoids. Images show the expression of the progenitor marker SOX2, the neuronal marker NeuN and the proliferative marker BrdU.

D. Representative single channel images from BrdU pulse-chase experiments in 2-month-old 03231^p.Q503X organoids. Images show the expression of the progenitor marker SOX2, the neuronal marker NeuN and the proliferative marker BrdU.