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. 2005 Mar 22;387(Pt 1):85–91. doi: 10.1042/BJ20041230

Figure 1. Sequence alignment of CTR2, OPR and receptors of the OT/VP superfamily.

Figure 1

The amino acid sequence of CTR2 and OPR are aligned with those of the Octopus CTR1 [14], Lymnaea LSCPR1 and LSCPR2 [16,17], and the rat receptors (OxyR, V1aR and V2R [7,8,10]). Amino acid residues that are identical in all receptors are indicated by an asterisk. N-linked glycosylation sites are underlined. Potential phosphorylated serine or threonine residues are marked by open circles. Amino acid residues in shaded boxes are believed to play a pivotal role in the GPCR activation, and those in boxes are highly conserved in the vertebrate receptors of the OT/VP superfamily, but not in other GPCRs, and have been suggested to be important in receptor–ligand interactions [19]. Residues in the agonist-binding pocket, as described in the text, are shown by arrows. Horizontal lines above the sequnce indicate the seven putative TM domains. The nucleotide sequences have been deposited into the DDBJ, EMBL and GeneBank® databases under the accession numbers: CTR2, AB112347; OPR, AB116233.