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. 2024 Aug 14;18:1418973. doi: 10.3389/fnins.2024.1418973

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Copyright © 2024 Ruiz-Reig, Chehade, Yerna, Durá, Gailly and Tissir.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epileptic susceptibility in p53-cKO mice. (A,B) No differences were observed in terms of size (A) and weight (B) between control and p53-cKO mice up to 2 months. (C) Mutant brains are macroscopically similar to control brains. (D) In order to analyze epileptic susceptibility, 2-month-old mice (P60) were injected with Pentylenetetrazol (PTZ), and their behavior was observed for 30 min. (E) Increased epileptic susceptibility was observed from the second day of injection (Ctrl: 1 n = 4; p53-cKO: 3.2 ± 0.9 n = 5) and significantly different in the third day of injection (Ctrl: 1 n = 4; p53-cKO: 3.6 ± 0.87 n = 5; p = 0.034). Values were obtained by unpaired Student’s t-test; *p < 0.05, **p < 0.01, and ***p < 0.001. Scale bar (A) 1.7 mm.