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. 2024 Aug 14;18:1418973. doi: 10.3389/fnins.2024.1418973

Figure 4.

Figure 4

The lack of p53 increases the number of Sox2+ progenitors in the hippocampus. (A,A’) Coronal section immunolabeled with Sox2 and Ki-67 antibodies at the level of the dentate gyrus of control (A) and p53-cKO mice (A’) at P60. The dashed line delineated the SGZ of the hippocampus. (B) Quantification of the density of Sox2 positive cells in the SGZ of the hippocampus. (C) Quantification of Sox2 and Ki-67 positive cells among the Sox2 positive population in the SGZ. (D,D′) Coronal sections at the level of the DG stained with TUNEL in control (D) and mutant mice (D′). (E) Quantification of TUNEL positive cells in the GCL per dentate gyrus. GCL, granula cell layer; SGCL, superior granular cell layer; IGCL, inferior granular cell layer; H-SGZ, Hilus-subgranular zone. Values were obtained by unpaired Student’s t-test; *p < 0.05, **p < 0.01, and ***p < 0.001. Scale bar (A’,D′) 100 μm.