Table 2.
TSH, fT4, and T3 concentrations pre- and post-thyroidectomy for pediatric patients on LT4 monotherapy.
| GD N = 53 |
DTC N = 55 |
|||||
|---|---|---|---|---|---|---|
| Pre-TT | Post-TT | P-Value | Pre-TT | Post-TT | P-Value | |
| TFT* | ||||||
| TSH, mIU/L | ||||||
| Mean (SD) | 1.51 (3.57) | 2.41 (1.08) | 0.101 | 2.60 (1.68) | 0.21 (0.15) | <0.0001 |
| [95% CI] | 0.55–2.47 | 2.12–2.70 | 2.15–3.04 | 0.17–0.24 | ||
| fT4, ng/dL | ||||||
| Mean (SD) | 1.97 (1.91) | 1.52 (0.31) | 0.098 | 1.19 (0.20) | 1.64 (0.31) | <0.0001 |
| [95% CI] | 1.45–2.48 | 1.44–1.60 | 1.14–1.24 | 1.56–1.72 | ||
| T3, ng/dL | ||||||
| Mean (SD) | 235.0 (170.6) | 108.4 (19.9) | <0.0001 | 139.3 (45.9) | 129.1 (27.8) | 0.08 |
| [95% CI] | 180.5–289.5 | 103.1–113.8 | 127.2–151.4 | 121.7–136.4 | ||
| Ratio [(fT4*100)/T3 | ||||||
| Mean (SD) | 0.82 (0.41) | 1.44 (0.34) | <0.0001 | 0.92 (0.26) | 1.33 (0.36) | <0.0001 |
| [95% CI] | 0.71–0.93 | 1.35–1.53 | 0.85–0.99 | 1.23–1.42 | ||
*Reference ranges for TSH, fT4, and T3 were collected from the assay performed. The mean treatment duration post-TT was 1 year ± 3 months.
GD, Graves’ Disease; DTC, Differentiated Thyroid Cancer; TFT, Thyroid Function Test; TSH, Thyroid Stimulating Hormone; fT4, free Thyroxine; T3, Triiodothyronine; TT, Total Thyroidectomy.