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. 2005 Apr 5;387(Pt 2):429–436. doi: 10.1042/BJ20040786

Figure 2. RyRs are activated by the DHPR C-region peptide CS in the cytoplasmic bath.

Figure 2

(A) Current traces in a single experiment on two RyRs. The current baselines are denoted by the broken lines and channel openings are seen as upward current transitions. Channels were recorded (a) in cis/trans 250 mM/50 mM Cs+, 0.1 mM/1 mM Ca2+, (b) during exposure to 1 μM CS, (c) 15 s after removal of CS from the solution, (d) during a second exposure to 1 μM CS and (e) after removal again of the peptide. Reapplication of CS produced no additional increase in channel activity. (B) Two RyRs are activated by 2 mM ATP+0.5 mM Ca2+ (free [Ca2+]=200 μM) in the cytoplasmic bath (a) under control conditions and (b) during exposure to 1 μM CS.