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. 2005 Apr 5;387(Pt 2):429–436. doi: 10.1042/BJ20040786

Figure 4. Activation of RyRs in the presence and absence of CS.

Figure 4

ATP (2 mM) alone (○, N=6), ATP+1 μM CS (●, N=4), ATP+75 μM CS (■, N=4). The curves show Hill fits (Hill coefficient=2) to each data set. The fitted Hill parameters are: (······), Ka=0.4 mM, Pmax=0.71, Pmin=0.13; (——), Ka=0.4 mM, Pmax=0.75 and Pmin=0.41; and (----), Ka=0.23 mM, Pmax=0.72 and Pmin=0.1. The baths contained (cis/trans) 250 mM/50 mM Cs+ and 0.1 mM/1 mM Ca2+ (free).