. 2005 Apr 5;387(Pt 2):429–436. doi: 10.1042/BJ20040786

Table 3. Summary of the parameters of Hill fits to the [Ca²⁺] and [Mg²⁺] dependences of P₀ in the absence and presence of DHPR C-region peptides.

P_max is the P₀ at low bivalent-ion concentration, K_i the half-inhibitory concentration of X²⁺ and n_i the Hill coefficient. N is the number of bilayers and n the number of channels measured.

DHPR C-region peptide	Experimental conditions	X²⁺	P_max	K_i (μM)	n_i	N	n
–	250 mM Cs⁺, 2 mM ATP	Ca²⁺	0.86±0.03	980±055	3.0±0.6	5	51
50 μM C_S	250 mM Cs⁺, 2 mM ATP	Ca²⁺	0.84±0.06	2300±400	2.6±1.1	4	31
–	100 mM Cs⁺, 2 mM ATP	Ca²⁺	0.73±0.06	210±037	2.0±0.5	3	40
50 μM C_S	100 mM Cs⁺, 2 mM ATP	Ca²⁺	0.49±0.05	460±071	4.5±2.8	3	40
–	100 mM Cs⁺, 2 mM ATP	Mg²⁺	0.69±0.07	250±40	2.3±0.7	5	70
50 μM C_S	100 mM Cs⁺, 2 mM ATP	Mg²⁺	0.46±0.07	420±110	2.7±2.0	6	65
25 μM C_S1	100 mM Cs⁺, 2 mM ATP	Mg²⁺	0.58±0.06	570±120	1.7±1.4	4	75
25 μM C_S2	100 mM Cs⁺, 2 mM ATP	Mg²⁺	0.62±0.07	350±41	3.2±2.0	4	12
^*Native	250 mM Cs⁺	Ca²⁺		710±80		18
^*MHS	250 mM Cs⁺	Ca²⁺		1160±220		13
^*Native	100 mM Cs⁺	Ca²⁺		204±32		18
^*MHS	100 mM Cs⁺	Ca²⁺		957±250		9

* Native and MHS refer to normal and malignant hyperthermia-susceptible RyRs respectively from pig skeletal muscles [39].

Table 3. Summary of the parameters of Hill fits to the [Ca2+] and [Mg2+] dependences of P0 in the absence and presence of DHPR C-region peptides.

Table 3. Summary of the parameters of Hill fits to the [Ca²⁺] and [Mg²⁺] dependences of P₀ in the absence and presence of DHPR C-region peptides.