Table 2.
Characteristics after ARDS induction and before VV-ECMO start in the three groups
| Variables | N | control | N | hypothermia | N | β-blocker | p-value |
|---|---|---|---|---|---|---|---|
| General parameters | |||||||
| Central temperature(℃) | 6 | 38.7 (38.6–38.8) | 9 | 38.3 (38.0–38.5) | 7 | 38.4 (38.2–38.5) | 0.005 |
| Hemoglobin level (g.dl−1) | 6 | 10.4 (9.7–10.7) | 9 | 9.0 (8.6–10.0) | 7 | 9.5 (9.0–10.2) | 0.15 |
| Hemodynamic parameters | |||||||
| Mean arterial pressure (mmHg) | 6 | 84 (78–85) | 9 | 69 (66–72) | 7 | 70 (65–70) | 0.012 |
| Heart rate (bpm) | 6 | 138 (124–142) | 9 | 153 (136–174) | 7 | 138 (133–140) | 0.22 |
| Cardiac output (l.min−1) | 6 | 7.9 (7.5–8.7) | 9 | 8.2 (7.5–9.4) | 7 | 7.6 (7.3–8.0) | 0.28 |
| Lactate (mmol.l−1) | 6 | 1.4 (0.9–1.5) | 9 | 1.0 (0.8–1.7) | 7 | 1.8 (1.0–2.1) | 0.65 |
| Norepinephrine dose (γg.kg−1.min−1) | 6 | 0.5 (0.4–0.6) | 9 | 1.1 (0.8–4.5) | 7 | 0.4 (0.3–1.0) | 0.019 |
| *Fluid expansion (ml) | 6 | 500 (500–1000) | 9 | 900 (750–1000) | 7 | 1000 (1000–1500) | 0.041 |
| Respiratory parameters | |||||||
| Sao2 (%) | 6 | 74 (67–80) | 9 | 79 (78–85) | 7 | 77 (72–81) | 0.14 |
| Pao2/fio2 | 6 | 48 (44–55) | 9 | 57 (55–60) | 7 | 54 (45–60) | 0.14 |
| Fio2 (%) | 6 | 100 (100–100) | 9 | 100 (100–100) | 7 | 100 (100–100) | - |
| Static compliance (ml.cmh2O−1) | 6 | 24 (23–25) | 9 | 21 (17–24) | 7 | 20 (19–20) | 0.048 |
Data are expressed as median, 25 e and 75e quantile. *Sum of fluids administered during the ARDS procedure