Table 3.
PRS predictors associated with hearing difficulty in the UK Biobank cohort (N = 425,240)
| PGS ID | Reported trait | Trait category | Beta | FDR p-value |
|---|---|---|---|---|
| PGS000762 | Hearing difficulties | Sensory | 1.09 | <E−300 |
| PGS002161 | Body mass index (BMI) | Metabolic | 0.07 | 9.18E−84 |
| PGS002313 | Body mass index (BMI) | Metabolic | 0.07 | 1.99E−81 |
| PGS001943 | Body mass index (BMI) | Metabolic | 0.07 | 4.26E−81 |
| PGS002679 | Body mass index (BMI) | Metabolic | 0.07 | 1.43E−80 |
| PGS002348 | Smoking status | Lifestyle | 0.07 | 1.33E−79 |
| PGS002096 | Abdominal pain | Digestive | 0.07 | 2.02E−74 |
| PGS000910 | Body mass index (BMI) | Metabolic | 0.07 | 8.78E−74 |
| PGS000921 | Body mass index (BMI) | Metabolic | 0.07 | 9.65E−69 |
| PGS001054 | Snoring | Sleep | 0.05 | 3.27E−41 |
| PGS001995 | Daytime dozing/sleeping (narcolepsy) | Sleep | 0.05 | 2.96E−40 |
| PGS001830 | Tobacco use disorder | Lifestyle | 0.04 | 1.59E−28 |
| PGS001961 | Impedance of whole body | Metabolic | −0.04 | 2.06E−28 |
| PGS002179 | Impedance of whole body | Metabolic | −0.04 | 3.81E−28 |
| PGS000145 | Depression (ICD-10 defined) | Mental health | 0.04 | 4.04E−25 |
| PGS001154 | Impedance (left arm) | Metabolic | −0.03 | 2.84E−20 |
| PGS001161 | Whole body impedance | Metabolic | −0.03 | 4.70E−20 |
| PGS000320 | Body mass index | Metabolic | 0.04 | 2.40E−19 |
| PGS000926 | Daytime dozing/sleeping (narcolepsy) | Sleep | 0.03 | 9.05E−19 |
| PGS002329 | HDL cholesterol | Cardiovascular | −0.03 | 1.35E−18 |
| PGS001156 | Impedance (right arm) | Metabolic | −0.03 | 1.51E−18 |
| PGS002695 | HDL cholesterol | Cardiovascular | −0.03 | 5.00E−17 |
| PGS001954 | HDL cholesterol | Cardiovascular | −0.03 | 1.60E−16 |
| PGS002140 | Wears glasses or contact lenses | Sensory | 0.03 | 9.40E−16 |
| PGS001108 | Basal metabolic rate | Metabolic | 0.03 | 2.03E−14 |
| PGS001959 | High light scatter reticulocyte count | Hematopoietic | 0.03 | 1.74E−13 |
| PGS001976 | Reticulocyte count | Hematopoietic | 0.03 | 2.75E−13 |
| PGS000995 | Dentures | Musculoskeletal | 0.03 | 9.49E−13 |
| PGS001950 | Whole body fat-free mass | Metabolic | 0.03 | 9.49E−13 |
| PGS001234 | Left arm mass (predicted) | Metabolic | 0.03 | 3.80E−12 |
| PGS001165 | Arm fat-free mass (L) | Metabolic | 0.03 | 5.64E−12 |
| PGS002470 | Systolic blood pressure | Cardiovascular | −0.04 | 3.29E−09 |
| PGS001002 | Whole body water mass | Metabolic | 0.02 | 3.40E−09 |
| PGS001146 | Arm fat-free mass (R) | Metabolic | 0.02 | 3.70E−09 |
| PGS001169 | Whole body fat-free mass | Metabolic | 0.02 | 5.14E−09 |
| PGS001235 | Right arm mass (predicted) | Metabolic | 0.02 | 7.36E−09 |
| PGS002101 | Apolipoprotein A | Cardiovascular | −0.02 | 1.20E−07 |
| PGS001846 | Hemorrhoids | Digestive | 0.02 | 6.40E−06 |
| PGS002399 | Forced vital capacity | Cardiovascular | −0.02 | 4.25E−05 |
| PGS002450 | HDL cholesterol | Cardiovascular | −0.03 | 7.58E−05 |
| PGS001168 | Trunk fat-free mass | Metabolic | 0.01 | 2.84E−04 |
| PGS001160 | Trunk mass (predicted) | Metabolic | 0.01 | 5.62E−04 |
| PGS000901 | Systolic blood pressure (male) | Cardiovascular | −0.01 | 1.35E−03 |
| PGS002491 | Diabetes (any type) | Metabolic | 0.35 | 2.07E−03 |
| PGS000356 | Any cancer | Neoplasm | 0.01 | 4.57E−03 |
| PGS002524 | Type 2 diabetes | Metabolic | 0.32 | 5.93E−03 |
| PGS002405 | High light scatter reticulocyte count | Hematopoietic | 0.01 | 6.84E−03 |
| PGS002040 | Retinal detachments and defects | Sensory | −0.01 | 2.81E−02 |
| PGS002401 | HDL cholesterol | Cardiovascular | −0.01 | 3.26E−02 |
| PGS000272 | Pappalysin-1 (PAPPA) serum levels | Hematopoietic | 0.01 | 4.33E−02 |
These PRS predictors achieved the highest replication score in the replication cohort, indicating that the results were replicated for HTs and DPOAEs for both ears