Table 3.
The minimal inhibitory concentrations and the susceptibilities of cefoperazone alone and in combination with sulbactam (1:1) against Klebsiella pneumoniae isolates
| K. pneumoniae (n = 201) | MIC (ug/ml) | Susceptibility [%(n)]a | |||||
|---|---|---|---|---|---|---|---|
| MIC50 | MIC90 | MIC range | S | I | R | ||
| CPZ | 0.25 | > 64 | 0.0625 ~ > 64 | 77.61% (156) | 3.98% (8) | 18.41% (37) | |
| CPZ/SUL | 0.25 | 32 | 0.0625 ~ > 64 | 89.55% (180) | 2.99% (6) | 7.46% (15) | |
|
CPZnS K. pneumoniae (n = 45) |
MIC (ug/ml) | Susceptibility [%(n)]a | |||||
| MIC50 | MIC90 | MIC range | S | I | R | ||
| CPZ | > 64 | > 64 | 32 ~ > 64 | 0.00% (0) | 17.78% (8) | 82.22% (37) | |
| CPZ/SUL | 16 | > 64 | 2 ~ > 64 | 53.33% (24) | 13.33% (6) | 33.33% (15) | |
aThe susceptibility breakpoints were adapted from Clinical and Laboratory Standards Institute 2019 for cefoperzaone against Enterobacterales: S, MIC ≤ 16 mg/L; I, MIC = 32 mg/L; R, MIC ≥ 64 mg
CPZnS, cefoperazone-non-susceptible; CPZ, cefoperazone; SUL, sulbactam; CPZ/SUL, cefoperazone/sulbactam; MIC, minimal inhibitory concentration