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. 2024 Aug 27;14:19899. doi: 10.1038/s41598-024-70911-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — Bulk RNA-seq analyses reveal the transcriptional alterations in MPP4. Bulk RNA-seq analysis identified significant differences in the transcriptional profiles of MPP4 between VDD and VDS (n = 3 per group). (a) The heatmap and dendrogram show a distinct clustering between VDD and VDS. (b) The volcano plot displays the − log10 adjusted p-values and log2 fold-change differences of the identified DEGs. Each dot represents a gene, and significant DEGs are indicated by red dots. (c) The GO enrichment analysis reveals that the up-regulated DEGs between VDD and VDS MPP4 are enriched in Leukocyte migration and chemotaxis-related genes. The dot plot shows the significance and the gene ratios of the top eight GO terms (left), and the Cnet plot indicates the identified DEGs of the top five GO terms (right). (d) The GO enrichment analysis reveals that the down-regulated DEGs between VDD and VDS MPP4 are enriched in the regulation of hematopoiesis-related genes. The dot plot shows the significance and the gene ratios of the top eight GO terms (left), and the Cnet plot indicates the identified DEGs of the top five GO terms (right).