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. 2005 Apr 26;387(Pt 3):649–658. doi: 10.1042/BJ20041729

Figure 7. Schematic diagram depicting interactions of Lsb5 with other proteins involved in actin remodelling and endocytosis.

Figure 7

In the present study and in previous work [14], we have identified interaction sites between Lsb5p and Sla1p. This interaction occurs between the HD1 (1) domain of Sla1 and most likely the NPF motif (N) of Lsb5p. The interaction appears to be stabilized by the presence of the GAT domain (G). The GAT domain of Lsb5 is most likely to interact with Arf3. Our studies, and those of Madania et al. [15], indicate that the VHS domain of Lsb5 is the domain likely to interact with Las17p. Other domains and proteins depicted: S1, S2, S3, Src homology 3 domains 1, 2 and 3 of Sla1; 2, HD2 of Sla1; Ct, C-terminal repeats region of Sla1; P, Pan1p; E, End3p. Arf3*, active Arf3.