Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Aug 27;9:63. doi: 10.1186/s41181-024-00289-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

PMC Copyright notice

Fig. 4 — DESI TQ MS to image LBT-999 and dopamine accumulations. a. From left to right, ion images of two lipids (potassiated PC(36:4) and protonated PC (36:2)), dopamine (154.1 > 137.1), and LBT-999 (332.1 > 154.1) acquired using the DESI TQ-XS mass spectrometer of sagittal brain sections from rats injected with LBT-999 at the dose of 0.02 mg/kg (upper panel), and a DAT antagonist (GBR12909, 12.5 mg/kg) 15 min before 0.02 mg/kg LBT-999 injection (lower panel). Arrows pointing the SN/VTA. Spatial resolution 50 µm. b. Relative quantification of dopamine and LBT-999 intensities relative to the signals from the lipids measured in the striatum in a rat injected with LBT-999 (0.02 mg/kg), and in a rat pre-treated with GBR12909 (12.5 mg/kg) 15 min before LBT-999 injection (0.02 mg/kg)