Table 2.
Cerebral biodistribution in rats after a 0.02 or 0.0002 mg/kg injection of LBT-999
| Rat weight (g) | Injected dose of LBT-999 (mg/kg) | Brain area | Weight of the dissected area (mg) | LBT-999 concentration (ng/g tissue) | % of injected dose/g tissue |
|---|---|---|---|---|---|
| 292 | 0.02 | Striatum | 40.2 | 98.3 | 1.69 |
| Cortex | 179.1 | 5.8 | 0.10 | ||
| Hippocampus | 73.1 | 4.6 | 0.08 | ||
| Cerebellum | 46.9 | 4.7 | 0.08 | ||
| 366 | 0.0002 | Striatum | 36.3 | 1.8 | 2.49 |
| Cortex | 181.7 | ND | ND | ||
| Hippocampus | 69.9 | ND | ND | ||
| Cerebellum | 56.0 | ND | ND |
Percentages of injected dose/g of tissues were determined 60 min after injection