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. 2005 Apr 26;387(Pt 3):695–702. doi: 10.1042/BJ20041624

Figure 6. Conformational changes of HSA induced by fatty acid binding depicted based on the crystal structure of HSA complexed with AA.

Figure 6

The rotation of the side chains of Lys-402 (domain IIIA) and Lys-541 (domain IIIB) towards each other upon binding to a fatty acid is suggested. In addition, depicted is the movement of the side chains of Lys-205 from domain IIA and Lys-466 from domain IIIA closer towards each other upon binding of polyunsaturated AA or DHA. The cross-linking resulting from these movements is indicated. Fatty acid molecules are represented in space-filling form, and their binding sites shown in the right panel are based on the PDB entry 1gnj.