Table 3.

The ADME analysis of investigated ligands.

Ligand	GI absorption	BBB permeant	Pgp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
F	High	Yes	Yes	No	Yes	Yes	No	Yes
G	High	Yes	Yes	No	Yes	Yes	No	Yes