TABLE 1.
Participant demographics of each imaging cohort.
| Patient characteristics for each imaging cohort | |||
|---|---|---|---|
| MRI | Aβ | Tau | |
| Participants, n | 206 | 61 | 58 |
| Sex, n (%) | |||
| Female | 113 (54.9) | 27 (44.3) | 34 (58.6) |
| Male | 93 (45.1) | 34 (55.7) | 24 (41.4) |
| Age (Years) | 69.9 ± 8.0 | 69.4 ± 8.4 | 69.7 ± 8.3 |
| Race | |||
| White | 187 (90.8) | 57 (93.4) | 54 (93.1) |
| Black | 10 (4.9) | 2 (3.3) | 3 (5.2) |
| Asian | 2 (1.0) | 0 (0.0) | 0 (0.0) |
| Other | 7 (3.3) | 2 (3.3) | 1 (1.7) |
| Cognitive diagnosis | |||
| Healthy | 129 (62.6) | 35 (57.4) | 33(56.9) |
| MCI | 41 (19.9) | 17 (27.9) | 17 (29.3) |
| AD | 36 (17.5) | 9 (14.8) | 8 (13.8) |
| Other | |||
| Assessment performance (Avg ± SD) | |||
| Grip strength | 96.9 ± 10.9 | 98.1 ± 10.6 | 97.8 ± 10.5 |
| Walking speed | 92.1 ± 13.6 | 91.4 ± 13.3 | 89.7 ± 12.0 |
| Dexterity | 94.0 ± 13.9 | 93.3 ± 18.9 | 92.2 ± 13.0 |
| Biomarker positive n, (%) | – | 23 (37.7) | 13 (22.4) |
| Biomarker burden, SUVR, (Avg ± SD) | |||
| Precentral cortex | – | 1.1 ± 0.1 | 0.98 ± 0.1 |
| Parahippocampus | – | 1.1 ± 0.2 | 1.2 ± 0.2 |
| Hippocampus/entorhinal cortex | – | 1.1 ± 0.1 | 1.3 ± 0.2 |
| Cortical thickness in ROIs, mm, (Avg ± SD) | |||
| Precentral cortex | 2.46 ± 0.1 | 2.45 ± 0.1 | 2.44 ± 0.1 |
| Parahippocampus | 2.58 ± 0.2 | 2.60 ± 0.2 | 2.60 ± 0.2 |
| Hippocampus/entorhinal cortex | 3.22 ± 0.4 | 3.22 ± 0.4 | 3.23 ± 0.4 |
Note: All 206 study participants underwent MR imaging. Cognitive diagnosis was determined in lieu of pathology imaging within categories: cognitively healthy, MCI, and AD. Each PET imaging cohort represents a subset of participants who underwent additional PET imaging.
Abbreviations: Aβ, amyloid beta; AD, Alzheimer's disease; MR, magnetic resonance; PET, positron emission tomography; ROI, region of interest; SD, standard deviation; SUVR, standardized uptake value ratio.