TABLE 2.

This table includes results from linear regression analysis using motor performance as the predictor and biomarker burden in select ROIs as outcomes.

Linear regression analysis predicting each NIH motor assessment outcome by ROI biomarker burden
	Grip		Walking speed		Dexterity
Neurodegeneration	β	p	β	p	β	p
Precentral cortex	0.003	0.957	0.227	0.001	0.213	0.003
Parahippocampus	0.109	0.054	0.087	0.232	0.212	0.004
Entorhinal cortex	0.079	0.166	0.127	0.082	0.278	0.0001
Aβ burden
Precentral cortex	0.071	0.464	0.191	0.157	0.426	0.001
Parahippocampus	0.080	0.403	0.185	0.166	0.263	0.046
Hippocampus	0.059	0.532	0.114	0.391	0.085	0.521
Tau burden
Precentral cortex	0.105	0.256	0.101	0.474	0.530	<0.0001
Parahippocampus	0.045	0.623	0.010	0.945	0.477	0.0002
Hippocampus	0.124	0.182	0.012	0.932	0.341	0.011

Note: All models controlled for participant age and sex and corrected for multiple comparisons using the Benjamini–Hochberg (1995) procedure. The NIH motor assessment outcomes included the grip strength dynamometer, 2‐minute walking speed, and 9‐hole peg dexterity tests.

Abbreviations: Aβ, amyloid beta; NIH, National Institutes of Health; ROI, region of interest. Statistically significant P values are bolded.