TABLE 3.

This table includes results from linear regression analysis of our cognitively healthy subgroup using motor performance as the predictor and biomarker burden in select ROIs as outcomes.

Linear regression analysis predicting each NIH motor assessment outcome by ROI biomarker burden for those cognitively healthy
	Grip		Walking speed		Dexterity
Neurodegeneration	β	p	β	p	β	p
Precentral cortex	0.046	0.519	0.181	0.036	0.172	0.072
Parahippocampus	0.135	0.135	0.053	0.544	4.147	0.015
Entorhinal	0.053	0.462	0.111	0.212	0.283	0.003
Aβ burden
Precentral cortex	−0.082	0.508	−0.205	0.294	−0.025	0.897
Parahippocampus	−0.165	0.173	−0.195	0.278	−0.158	0.408
Hippocampus	−0.059	0.622	0.091	0.686	0.021	0.911
Tau burden
Precentral cortex	−0.120	0.321	−0.386	0.046	−0.065	0.754
Parahippocampus	−0.251	0.036	−0.195	0.276	−0.220	0.292
Hippocampus	−0.141	0.296	−0.173	0.440	−0.401	0.072

Note: All models were controlled for participant age and sex and corrected for multiple comparisons using the Benjamini–Hochberg (1995) procedure. The NIH motor assessment outcomes included the grip strength dynamometer, 2‐minute walking speed, and 9‐hole peg dexterity tests.

Abbreviations: Aβ, amyloid beta; NIH, National Institutes of Health; ROI, region of interest.