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. 2024 Jun 28;20(8):5132–5142. doi: 10.1002/alz.13909

TABLE 2.

Receiver‐operating characteristic (ROC) curves for AβX‐40, AβX‐42, and AβX‐42/AβX‐40 in plasma IP‐eluates for prediction of amyloid positivity by Aβ42/Aβ40 classification in CSF.

tp tn fp fn ppv npv Sensitivity Specificity BACC AUC
Aβ40 94 118 88 75 0.516 0.611 0.556 0.573 0.565 0.563
Aβ42 94 123 83 77 0.531 0.615 0.550 0.597 0.573 0.587
Aβ42/Aβ40 130 156 50 39 0.722 0.800 0.769 0.757 0.763 0.813
Aβ42/Aβ40 + ApoE ε4 147 150 53 22 0.735 0.872 0.870 0.739 0.804 0.865

Abbreviations: AUC, area under the curves; BACC, balanced accuracy; fn, false negative; fp, false positive; npv, negative predictive value; ppv, positive predictive value; tn, true negative; tp, true positive.