TABLE 3.

Cox proportional hazards regression based on clinical progression over time using three different models.

	Model 1		Model 2		Model 3
	HR (95% CI)	p‐value	HR (95% CI)	p‐value	HR (95% CI)	p‐value
Outcome: Dementia
Whole sample	6.53 (2.84–15.03)	<0.001	6.51 (2.76–15.34)	<0.001	4.38 (1.77–10.85)	0.001
MCI group	2.76 (1.12–6.82)	0.028	3.28 (1.29–8.37)	0.013	2.49 (0.87–7.17)	0.09
Outcome: MCI
Control group	3.05 (0.76–12.20)	0.115	3.75 (0.90–15.64)	0.07	4.62 (1.05–20.28)	0.043
SCD group	2.10 (1.29–3.44)	0.003	1.78 (1.04–3.04)	0.035	1.58 (0.90–2.77)	0.11

Notes: Results of Cox proportional hazards regression models analyzing the association between low baseline Aβ42/Aβ40 IP eluates from plasma and the risk of clinical progression to dementia (whole sample, MCI group) or MCI (control group, SCD group). Model 1: no covariate adjustment; Model 2: adjusted for baseline age, sex, and years of education; Model 3: additional adjustment for APOE ε4 status.

Abbreviations: HR, hazard ratio; MCI, mild cognitive impairment; SCD, subjective cognitive decline.