TABLE 2.

Top regions identified in gene‐based analysis.

				Model 1					Model 2
Gene	Chromosome	Start BP (hg37)	Stop BP (hg37)	No. of SNPs	No. of parameters	N	Z Statistic	p‐Value	No. of SNPs	No. of parameters	N	Z Statistic	p‐Value
Novel regions
C9orf139	9	139886916	139941234	358	74	9095	3.28	5.27×10−4	356	68	8917	3.85	5.92×10−5 *
SNX31	8	101575116	101710643	1163	151	9095	3.01	1.31×10−3	1156	146	8917	3.81	6.83×10−5 *
Previously reported regions
APOE	19	45374011	45422650	342	85	9095	9.18	2.23×10−20 **	343	85	8917	1.77	0.04
LARP1B	4	128947423	129154086	1053	81	9095	3.81	6.88×10−5 *	1211	93	8917	2.32	0.01
TREM2	6	41116244	41165924	380	62	9095	3.55	1.93×10−4	379	72	8917	4.14	1.76×10−5 *
SERPINB13	18	61219223	61281873	560	76	9095	3.43	2.97×10−4	555	78	8917	4.02	2.94×10−5 *
ABCA7	19	1005102	1075571	765	116	9095	3.14	8.46×10−4	765	116	8917	3.78	7.76×10−5 *

Abbreviations: BP, base pair; SNP, single nucleotide polymorphism.

^a Model 1 is adjusted for age, sex, and population stratification (PCs).

^b Model 2 is adjusted for age, sex, PCs, and APOE.

^*Suggestively associated at p < 9×10⁻⁵.

^**Significant at the Bonferroni corrected threshold of 2.59×10⁻⁶.