TABLE 3.

Results of pathway analysis.

GO number	Pathway	Model	No. of genes	β	SE	p‐Value
GO:0010915	regulation of very‐low‐density lipoprotein particle clearance	1	4	3.25	0.59	2.07×10−8
GO:0051103	DNA ligation involved in DNA repair	1,2 *	9	1.54	0.36	1.11×10−5
GO:0015347	sodium‐independent organic anion transmembrane transporter activity	1	16	0.84	0.20	2.11×10−5
GO:0043252	sodium‐independent organic anion transport	1	15	0.81	0.21	7.82×10−5
GO:0034596	phosphatidylinositol phosphate 4‐phosphatase activity	2	8	1.14	0.30	9.25×10−5
GO:0010669	epithelial structure maintenance	2	28	0.55	0.15	1.53×10−4
GO:0050890	cognition	2	281	0.17	0.05	1.70×10−4
GO:0000405	bubble DNA binding	2	8	1.00	0.29	2.81×10−4
GO:0019199	transmembrane receptor protein kinase activity	1	80	0.32	0.09	3.64×10−4
GO:0097350	neutrophil clearance	1,2 *	5	1.18	0.35	3.95×10−4
GO:0070327	thyroid hormone transport	1	5	1.09	0.33	4.14×10−4
GO:0042180	cellular ketone metabolic process	1	188	0.19	0.06	4.15×10−4
GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly	1	14	0.70	0.21	4.26×10−4
GO:0009649	entrainment of circadian clock	1	26	0.55	0.16	4.36×10−4
GO:0060260	regulation of transcription initiation from RNA polymerase II promoter	1	26	0.52	0.16	4.39×10−4
GO:0043194	axon initial segment	2	20	0.59	0.18	4.96×10−4

^a Model 1 is adjusted for age, sex, and population stratification (PCs).

^b Model 2 is adjusted for age, sex, PCs, and APOE.

^*Results shown for Model 1.