Table 2. IC50 values for hTACE truncates and C184A mutants.
IC50 (nM) | |||
---|---|---|---|
TACE form | GW9471 | GW4023 | GW1988 |
hR473 wild-type | 46.0±6.2 | 736±203 | 33.4±12.6 |
hR473 C184A | 44.6±12.0 | 767±179 | 31.8±23.5 |
hR651 wild-type | 48.2±5.6 | 851±94 | 34.4±13.0 |
hR651 C184A | 48.7±5.3 | 836±407 | 43.2±13.5 |