TABLE 3.
Pairwise comparisons of the marginal means and 95% confidence interval for technical factors including reference region (RR), target type, RR type, and quantification space before and after harmonization.
| Pairwise comparisons | |||
|---|---|---|---|
| (A) Amyloid‐negative group | (B) Amyloid‐positive group | ||
| Estimates | Estimates | ||
| Harm_Status | ∆CL (Harmonized‐Original) (95% CI) | Harm_Status | ∆CL (Harmonized‐Original) (95% CI) |
| Harmonized‐Original | 2.88 (1.84 to 3.91) | Harmonized‐Original | −1.90 (−2.25 to −1.55) |
| Reference region (RR) | ∆CL (Harmonized‐Original) (95% CI) | Reference region (RR) | ∆CL (Harmonized‐Original) (95% CI) |
| WCB | 2.24 (3.38 to 1.10) | WCB | −2.79 (−3.18 to −2.42) |
| CGM | −1.70 (−3.11 to −0.29) | CGM | −8.30 (−8.92 to −7.68) |
| WCB+BSTM | 3.45 (2.44 to 4.47) | WCB+BSTM | −1.10 (−1.44 to −0.76) |
| Pons | 7.52 (6.84 to 8.20) | Pons | 4.59 (4.21 to 4.96) |
| Target type | ∆CL (Harmonized‐Original) (95% CI) | Targettype | ∆CL (Harmonized‐Original) (95% CI) |
| Subject‐based | 3.62 (2.55 to 4.68) | Subject‐based | −3.63 (−4.16 to −3.10) |
| GAAIN | 2.14 (1.12 to 3.16) | GAAIN | 2.14 (1.12 to 3.16) |
| RR type | ∆CL (Harmonized‐Original) (95% CI) | RR type | ∆CL (Harmonized‐Original) (95% CI) |
| Subject‐based | 3.01 (2.17 to 3.85) | Subject‐based | −2.02 (−2.38 to −1.67) |
| GAAIN | 2.75 (1.52 to 3.98) | GAAIN | −1.77 (−2.14 to −1.41) |
| Space | ∆CL (Harmonized‐Original) (95% CI) | Space | ∆CL (Harmonized‐Original) (95% CI) |
| Native | 3.31 (3.02 to 3.60) | Native | −1.89 (−2.24 to −1.54) |
| MNI | 2.45 (0.56 to 4.34) | MNI | −1.91 (−2.27 to −1.55) |
Abbreviations: CGM, cerebellum gray matter; RR, reference region; WCB, whole cerebellum; WCB+BSTM, whole cerebellum plus brainstem.
Bold values indicate p‐values <0.05.