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Illustration of the effects of APOE ε4 on the amyloid cascade. Sex effects are observed downstream amyloid. Illustration of the available evidence showing no sex‐specific genetic drivers of amyloidosis but different effects of APOE ε4 in tau (lowering resistance in women) and cognition (lowering cognitive resilience in women compared to men). The magnitudes of the arrows are indicative of effect sizes, with larger arrows representing larger effects. APOE: apolipoprotein E
