Table 2.

List of recombinant proteins accumulated in tobacco vacuole

Protein	Signal origin	Expression level	Tobacco species	References
Avidin	PPI-I	1.5% TSP	N. benthamiana	[51]
Endolysin	PPI-I	160 mg/kg FW	N. benthamiana	[52]
Human collagen	BTPA	2% TSP	Tobacco	[53]
α-Galactosidase A	TCA	302 mg/kg FW	BY-2 cells	[54]
C5a	AFVY	10.62 mg/kg FW	N. tabacum	[55]
IL-6	AFVY	5.21 μg/kg TSP	N. tabacum	[56]
mAb 14D9	A11G	1.57%–1.73% TSP	N. tabacum	[57]

PPI-I, potato proteinase inhibitor I; BTPA, barley thiol protease aleurain; TCA, tobacco chitinase A; C5a, human complement factor 5a. AFVY, the C-terminal tetrapeptide of phaseolin; A11G, amaranth 11S globulin (KISIA Ct and NIFRGF ss)