Table 2.
Antibacterial activity (MIC, μg/mL) against Gram-negative bacteria of compounds 5a–5h and 9a–9h.
| Compd. | Gram-Negative Bacteria | |||
|---|---|---|---|---|
| K. p. 10031 | A. b. 19606 | E. c. 25922 | P. a. 27853 | |
| 5a | 128 | >128 | >128 | >128 |
| 5b | 16 | 16 | 32 | >128 |
| 5c | 16 | 32 | 128 | 32 |
| 5d | 128 | 128 | >128 | >128 |
| 5e | >128 | 128 | >128 | >128 |
| 5f | 8 | 8 | 8 | 32 |
| 5g | 4 | 8 | 16 | 128 |
| 5h | 8 | 4 | 8 | 16 |
| 9a | >128 | 128 | >128 | >128 |
| 9b | 32 | 32 | 128 | >128 |
| 9c | >128 | >128 | >128 | >128 |
| 9d | >128 | >128 | >128 | >128 |
| 9e | >128 | >128 | >128 | >128 |
| 9f | 16 | 64 | 128 | >128 |
| 9g | 8 | 4 | 4 | 32 |
| 9h | 8 | 4 | 4 | 16 |
| Van | 128 | 16 | 128 | >128 |
| Cos | 1 | 1 | 0.5 | 0.5 |
K. p. 10031: Klebsiella pneumonia ATCC10031; A. b. 19606: Acinetobacter baumannii ATCC19606; E. c. 25922: Escherichia coli ATCC25922, penicillin-susceptible strain; P. a. 27853: Pseudomonas aeruginosa ATCC27853, penicillin-susceptible strain. Van = vancomycin; Cos = colistin.