Table 3.
Associations between biomarkers and AAA growth as continuous variable
| Biomarker | β | p-value | Adjusted β1 | p-value1 | AUC2 | 95% CI2 |
|---|---|---|---|---|---|---|
| Hpx | -0.19 | < 0.001 | -0.17 | 0.003 | 0.68 | 0.57–0.78 |
| HO-1 | 0.12 | 0.19 | -0.009 | 0.42 | 0.58 | 0.47–0.69 |
| Heme | 0.07 | 0.13 | 0.06 | 0.28 | 0.70 | 0.60–0.80 |
| Hb | 0.16 | 0.002 | 0.13 | 0.03 | 0.68 | 0.57–0.79 |
|
Hp (phenotype) Hp1-1 Hp2-1 Hp2-2 |
0.10 Ref 0.00 |
0.53 - 0.99 |
0.11 Ref 0.10 |
0.49 - 0.49 |
0.57 | 0.46–0.67 |
|
Hp (genotype) GG GA AA |
Ref -0.03 0.07 |
- 0.80 0.76 |
Ref -0.06 -0.27 |
- 0.63 0.43 |
0.52 | 0.42–0.62 |
Marker values were standardized, and AAA growth rate was natural logarithm (ln) transformed
Hpx: Hemopexin; HO-1: Heme-oxygenase-1; Hb: Hemoglobin; Hp: Haptoglobin; IL-6: interleukin-6
1 Adjusted for baseline diameter, IL-6, BMI and Metformin use
2 AUC and 95% CI calculated using ROC analysis with fast v/s slow growing AAA as outcome