Fig. 4.

Dynamics of core functional modules under different high-altitude hypoxia exposure stages based on 1079 SGBs. A Reaction steps of cobalamin biosynthesis. B Reaction steps of methanogenesis. KOs up-regulated or down-regulated (compared to the baseline) are in red or blue, respectively. KOs enriched in Blautia A genome are represented by solid line grid; missing KOs are represented by dotted line grid. The varying colors of the circles represent the classification of metabolites under the KEGG (Level 2) categorization