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. 2024 Aug 28;25:232. doi: 10.1186/s13059-024-03373-w

Fig. 6.

Fig. 6

Gavage feeding of B. wexlerae suppresses intestinal inflammation and promotes high-altitude acclimatization.A Design of animal experiments. The three groups are as follows: (1) PBS-fed in normoxia for 8 weeks (NOR+PBS); (2) PBS-fed in normoxia for 4 weeks and hypoxia for another 4 weeks (HYP+PBS); (3) B. wexlerae-fed in normoxia for 4 weeks and hypoxia for another 4 weeks (HYP+Bw). B Peripheral oxygen saturation (SpO2) of mice (n = 8 per group). C The quantification of pulmonary artery acceleration time (PAT) is converted by the formula [29] (detailed in “Methods”) (n = 6–7 per group). D Lung histological injury score of mice (n = 5 per group). E Representative H&E and Masson trichrome-stained of the mice lung sections (n = 5 per group). F Gross images of the mice distal ileum (n = 5 per group). G Representative H&E-stained sections of the mice distal ileum (n = 5 per group). H Statistical analysis of histological injury score of the mice distal ileum (n = 5 per group). I The relative mRNA expression levels of IL-1α and IL-1β in the ileum (n = 8 per group). J The relative mRNA expression level of ZO-1 in the ileum (n = 8 per group). Data are representative of at least three independent experiments (mean ± SE). *P < 0.05; **P < 0.01; ***P < 0.001; ns not significant (one-way ANOVA with Dunnett’s multiple comparisons test)