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. 2024 May 6;69(9):641–687. doi: 10.1177/07067437241245384

Table B.

CANMAT Criteria for Line of Treatment.

Line of treatment Criteria
First line

  • Level 1 or Level 2 evidence, plus clinical supporta
Second line

  • Level 3 evidence or higher, plus clinical supporta
Third line

  • Level 4 evidence or higher, plus clinical supporta
a

Clinical support refers to the application of expert consensus by the Canadian Network for Mood and Anxiety Treatments (CANMAT) editorial group to ensure that evidence-supported interventions are feasible and relevant to clinical practice. Therefore, treatments with higher levels of evidence may be downgraded to lower lines of treatment due to clinical issues such as side effects or safety profiles.