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. 2024 May 6;69(9):641–687. doi: 10.1177/07067437241245384

Table 6.3.

Risk of Antidepressant Discontinuation Symptoms.*

Risk of discontinuation symptoms Antidepressant
High risk

  • Paroxetine

  • Venlafaxine
Moderate risk

  • Citalopram

  • Desvenlafaxine

  • Duloxetine

  • Escitalopram

  • Fluvoxamine

  • Levomilnacipran

  • Milnacipran**

  • Sertraline

  • Vilazodone

  • Tricyclic antidepressants

  • Monoamine oxidase inhibitors
Low or minimal risk

  • Agomelatine**

  • Bupropion

  • Fluoxetine

  • Mirtazapine

  • Vortioxetine

*The risk categories are based on clinical studies, but the risk and severity of discontinuation symptoms may vary for individual patients and specific medications.

**Not available in Canada.