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. 2024 Jul 30;13(8):924. doi: 10.3390/antiox13080924

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Kinetic response of human primary lung fibroblasts to NRF2 activation: (A) NRF2 protein expression following transfection of hNRF2 cmRNAs in HPFs. Data are pooled results from 3 independent experiments (n = 1 donor) showing mean ± SD. * p < 0.05; ordinary one-way ANOVA with Dunnett’s multiple comparisons against eGFP-transfected control at each timepoint. The full Western blot images were cropped to the relevant NRF2 band. Relative gene expression following transfection of hNRF2 cmRNAs in HPFs of (B) HMOX1, (C) SRXN1, (D) GCLM, (E) TXNRD1, (F) NQO1. Data are pooled results from 3 independent experiments showing mean ± SD. (G) Secreted IL-8 (pg/mL) in the supernatant of HPF cultures at 6 h after treatment. Data are pooled results from 3 independent experiments (n = 1 donor) showing mean ± SD.

Kinetic response of human primary lung fibroblasts to NRF2 activation: (A) NRF2 protein expression following transfection of hNRF2 cmRNAs in HPFs. Data are pooled results from 3 independent experiments (n = 1 donor) showing mean ± SD. * p < 0.05; ordinary one-way ANOVA with Dunnett’s multiple comparisons against eGFP-transfected control at each timepoint. The full Western blot images were cropped to the relevant NRF2 band. Relative gene expression following transfection of hNRF2 cmRNAs in HPFs of (B) HMOX1, (C) SRXN1, (D) GCLM, (E) TXNRD1, (F) NQO1. Data are pooled results from 3 independent experiments showing mean ± SD. (G) Secreted IL-8 (pg/mL) in the supernatant of HPF cultures at 6 h after treatment. Data are pooled results from 3 independent experiments (n = 1 donor) showing mean ± SD.