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. 2024 Jul 30;13(8):924. doi: 10.3390/antiox13080924

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Response of human primary alveolar macrophages to NRF2 activation. Relative transcript levels in alveolar macrophages 6 h following hNRF2 cmRNA transfection or Compound 7 treatment of (A) HMOX1 (B) SRXN1 (C) GCLM, (D) TXNRD1 (E) NQO1 (F) CXCL8. Data are represented as the mean of duplicate samples in n = 6 donors ± SD. * p < 0.05 by ordinary one-way ANOVA with Sidak’s multiple comparisons (cmRNAs) or Dunnet’s multiple comparisons (Compound 7 vs. DMSO); ns: not significant.

Response of human primary alveolar macrophages to NRF2 activation. Relative transcript levels in alveolar macrophages 6 h following hNRF2 cmRNA transfection or Compound 7 treatment of (A) HMOX1 (B) SRXN1 (C) GCLM, (D) TXNRD1 (E) NQO1 (F) CXCL8. Data are represented as the mean of duplicate samples in n = 6 donors ± SD. * p < 0.05 by ordinary one-way ANOVA with Sidak’s multiple comparisons (cmRNAs) or Dunnet’s multiple comparisons (Compound 7 vs. DMSO); ns: not significant.