Fig. 8.

Mechanistic studies of WS disease processes in iPSC-derived OPCs/pmOLs (continued). a Quantification of cytosolic Ca²⁺ release by WS patient and isogenic OPCs/pmOLs after pharmacological activation of IP₃R-mediated Ca²⁺ release by addition of 10 µM ATP or 10 µM acetylcholine (ACh) to the culture medium. b Average traces of cytosolic Ca²⁺ release by WS patient and isogenic OPCs/pmOLs after pharmacological activation of IP₃R-mediated Ca²⁺ release. Data presented as mean ± SEM. n = 6 for patient line 1 and n = 5 for patient line 2. Statistics are reported in supplementary table S3