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. 2024 Jul 25;12(8):1657. doi: 10.3390/biomedicines12081657

Figure 3.

Figure 3

Association of rs2046210 with endometrial gene expression of ESR1 in women with and without endometriosis. (a). Relative ESR1 gene expression from tissues of women younger than 35 years with endometriosis (n = 25) is significantly increased compared to women without endometriosis (n = 18). Relative ESR1 gene expression between women with (n = 12) and without (n = 18) endometriosis does not differ in women older than 35 years. (b). ESR1 gene expression is significantly increased in women with endometriosis younger than 35 years with rs2046210 GA genotype (n = 10) compared to according controls (n = 6). No difference in relative ESR1 gene expression between cases (n = 10 or n = 5) and controls (n = 9 or n = 2) is seen in young women with homozygous major or minor rs2046210 genotype, respectively. (c). In women without endometriosis younger than 35 years, endometrial ESR1 gene expression is significantly reduced during secretory phase of menstrual cycle (n = 7) compared to proliferative phase (n = 9). In women with endometriosis younger than 35 years, ESR1 gene expression does not significantly differ between proliferative (n = 14) and secretory (n = 11) phase. (d). During secretory phase, women with endometriosis who are younger than 35 years and carry GA rs2046210 genotype (n = 3) show an increase in levels of ESR1 gene expression, compared to women with homozygous (GG + AA) rs2046210 genotypes (n = 8). ESR1 gene expression in this figure was normalized to levels of GAPDH expression, and data are presented as scatter dot plots including median relative expression levels for each group. Data were analyzed by Kruskal–Wallis test adjusted for multiple testing using Dunn’s multiple comparisons test (a–c) or Mann–Whitney test (d). Adjusted p-values (adjp) < 0.05 were considered significant, with non-significant differences indicated by ns. Controls: endometrial tissue of women without endometriosis, eutop: endometrial tissues from women with endometriosis, >35 y: women older than 35 years, ≤35 y: women younger or equal to 35 years.