Table 5.
The association of rs2046210 with endometriosis risk in patient subpopulations.
| Category | Patients | rs2046210 (GA vs. GG) | rs2046210 (GA + AA vs. GG) | rs2046210 (GA vs. GG + AA) |
||||
|---|---|---|---|---|---|---|---|---|
| n | % | OR (95%CI) | p-Value | OR (95%CI) | p-Value | OR (95%) | p-Value | |
| Stage | ||||||||
| low (RAFSI + II) | 66 | 46.8 | 2.24 (1.11 to 4.51) | 0.020 | 1.78 (0.92 to 3.48) | 0.084 | 2.41 (1.24 to 4.67) | 0.007 |
| high (RAFS III + IV) | 75 | 53.2 | 1.54 (0.78 to 3.03) | 0.202 | 1.43 (0.73 to 2.81) | 0.237 | 1.47 (0.78 to 2.78) | 0.230 |
| na | 10 | 6.6 | ||||||
| BMI | ||||||||
| low (< 25) | 161 | 67.9 | 2.27 (1.12 to 4.63) | 0.018 | 2.19 (1.12 to 4.29) | 0.022 | 2.01 (1.03 to 3.97) | 0.038 |
| high | 76 | 32.1 | 1.21 (0.43 to 3.41) | 0.702 | 0.93 (0.37 to 2.35) | 0.909 | 1.32 (0.51 to 3.48) | 0.556 |
| Age | ||||||||
| 18–34.9 | 126 | 53.2 | 3.54 (1.47 to 8.60) | 0.004 | 2.63 (1.21 to 5.70) | 0.015 | 3.03 (1.35 to 7.01) | 0.006 |
| 35–50 | 111 | 46.8 | 1.05 (0.47 to 2.35) | 0.920 | 0.98 (0.46 to 2.10) | 0.924 | 1.11 (0.52 to 2.41) | 0.774 |
| Fertility Status | ||||||||
| fertile | 43 | 35.5 | 1.67 (0.47 to 5.96) | 0.447 | 1.11 (0.35 to 3.50) | 0.889 | 2.14 (0.66 to 7.12) | 0.203 |
| infertile | 78 | 64.5 | 3.30 (1.24 to 8.91) | 0.016 | 2.96 (1.22 to 7.22) | 0.013 | 2.79 (1.10 to 7.24) | 0.022 |
| na | 116 | 49.0 | ||||||
| Gravidity | ||||||||
| 0 | 104 | 51.5 | 2.41 (0.97 to 6.01) | 0.057 | 2.14 (0.93 to 4.90) | 0.072 | 2.13 (0.92 to 5.05) | 0.083 |
| >0 | 98 | 48.5 | 1.42 (0.63 to 3.19) | 0.366 | 1.15 (0.54 to 2.45) | 0.778 | 1.61 (0.74 to 3.49) | 0.213 |
| na | 35 | 14.8 | ||||||
| Parity | ||||||||
| 0 | 144 | 72.0 | 1.45 (0.71 to 2.95) | 0.326 | 1.36 (0.69 to 2.66) | 0.349 | 1.43 (0.74 to 2.78) | 0.281 |
| >0 | 56 | 28.0 | 2.25 (0.74 to 6.95) | 0.141 | 1.63 (0.61 to 4.37) | 0.339 | 2.37 (0.82 to 6.98) | 0.098 |
| na | 37 | 15.6 | ||||||
Odds ratios of the genotypes of rs2046210 in the indicated subcategories are shown. Significant associations are highlighted in bold. OR, odds ratio; 95% CI, 95% confidence interval: RAFS, revised American Fertility Society Score; BMI, bod mass index; na, not assessed.