Table 4.

Correlations of the selected genes analyzed in the study in relation to AhR and “AhR-related signalling pathways” in diffuse (A) and intestinal (B) GC.

(A)
	Diffuse GC
Genes	AhR	AhR	AhRR	AhRR	CYP1B1	CYP1B1	CYP1A1	CYP1A1
	r	p value	r	p value	r	p value	r	p value
AhR	x		−0.031	0.92	−0.066	0.83	0.181	0.553
AhRR	−0.031	0.92	x		−0.107	0.73	0.711	0.007
CYP1B1	−0.066	0.83	−0.107	0.73	x		0.342	0.253
Growth factors and receptors (n = 10)
IGF1	0.184	0.55	0.865	0.0001	0.155	0.71	0.846	0.001
IGF1R	0.596	0.032	0.267	0.38	−0.159	0.6	0.345	0.24
FGFR1	−0.234	0.441	0.542	0.055	0.269	0.37	0.444	0.13
FGF7	0	1	0.576	0.04	−0.055	0.86	0.424	0.15
IGF2	0.041	0.89	0.119	0.7	−0.033	0.91	−0.043	0.69
IGFR2	0.562	0.046	0.375	0.21	−0.06	0.84	0.655	0.015
IRS1	−0.259	0.39	0.457	0.12	−0.121	0.69	0.384	0.19
IRS2	0.259	0.39	0.501	0.08	0.005	0.99	0.623	0.02
ERBB2	0.341	0.25	0.529	0.06	−0.676	0.01	0.291	0.34
EMT and migration (n = 10)
VIM	0.135	0.66	0.518	0.07	0.280	0.35	0.709	0.007
CDH1	0.501	0.08	0.57	0.09	−0.264	0.38	0.592	0.03
SNAI1	0.239	0.43	0.102	0.74	0.066	0.83	0.131	0.67
TGFB1	0.297	0.32	0.182	0.55	−0.511	0.83	−0.165	0.59
RUNX3	−0.771	0.8	0.202	0.51	−0.313	0.30	−0.065	0.83
SNAI2	0.317	0.29	0.441	0.13	0.044	0.89	0.605	0.04
TWIST2	−0.005	0.99	0.667	0.013	0.115	0.71	0.504	0.08
ZEB2	0.033	0.91	0.661	0.014	−0.038	0.90	0.602	0.04
RHOA	0.600	0.034	0.176	0.56	−0.203	0.50	0.484	0.09
RHOB	−0.215	0.48	0.295	0.23	0.429	0.14	0.444	0.13
Cell proliferation and migration (n = 3)
Ki67	0.463	0.11	0.328	0.27	−0.176	0.56	0.537	0.26
MMP2	−0.099	0.74	0.774	0.002	0.164	0.59	0.701	0.01
MMP9	0.193	0.53	0.005	0.99	−0.511	0.07	−0.271	0.32
Immunity (n = 5)
IDO1	0.528	0.07	−0.228	0.44	−0.440	0.13	−0.245	0.42
TDO2	0.267	0.38	0.330	0.27	−0.280	0.35	0.048	0.87
PD1	0.534	0.06	0.033	0.92	0.115	0.71	0.209	0.49
CD274	0.446	0.13	−0.437	0.13	−0.060	0.85	−0.435	0.11
PDL2	0.332	0.26	0.080	0.79	0.091	0.77	0.266	0.38
Angiogenesis (n = 6)
FLT1	0.559	0.047	0.303	0.31	0.214	0.48	0.319	0.29
VEGF165	0.402	0.17	0.358	0.23	0.011	0.97	0.364	0.22
VEGF189	0.306	0.31	0.088	0.77	−0.137	0.65	0.114	0.71
KDR	−0.187	0.54	−0.151	0.62	−0.368	0.22	−0.387	0.19
VEGFC	0.179	0.56	0.328	0.27	0	1	0.199	0.51
NRP1	0.185	0.55	0.614	0.02	0.033	0.91	0.411	0.16
(B)
	Intestinal GC
Genes	AhR	AhR	AhRR	AhRR	CYP1B1	CYP1B1	CYP1A1	CYP1A1
	r	p value	r	p value	r	p value	r	p value
AhR	1		0.679	0.004	0.018	0.95	0.112	0.68
AhRR	0.679	0.004	1		0.253	0.34	0.241	0.368
CYP1B1	0.018	0.95	0.253	0.34	1		0.655	0.006
Growth factors and receptors (n = 10)
IGF1	−0.113	0.68	0.168	0.53	0.765	0.001	0.371	0.16
IGF1R	−0.053	0.84	0.077	0.78	0.667	0.005	0.521	0.04
FGFR1	−0.021	0.94	0.132	0.62	0.794	<0.0001	0.455	0.08
FGF7	−0.127	0.64	0.047	0.86	0.721	0.002	0.401	0.12
IGF2	−0.093	0.73	0.144	0.59	0.774	<0.0001	0.337	0.2
IGFR2	0.169	0.53	0.018	0.95	0.524	0.037	0.364	0.15
IRS1	0.056	0.84	0.471	0.07	0.915	<0.0001	0.531	0.05
IRS2	0.113	0.68	0.203	0.45	0.582	0.018	0.05	0.83
ERBB2	0.533	0.03	0.288	0.28	−0.141	0.602	0.097	0.72
EMT and migration (n = 10)
VIM	0.186	0.49	0.132	0.62	0.812	<0.0001	0.379	0.15
CDH1	0.284	0.286	0.085	0.75	0.051	0.85	0.214	0.43
SNAI1	0.087	0.75	0.068	0.8	0.577	0.02	0.241	0.37
TGFB1	0.21	0.39	−0.091	0.74	0.453	0.08	0.118	0.66
RUNX3	0.195	0.47	0.081	0.76	−0.199	0.46	−0.071	0.8
SNAI2	0.282	0.29	0.171	0.53	0.711	0.002	0.131	0.63
TWIST2	0.121	0.66	0.109	0.69	0.827	<0.0001	0.307	0.25
ZEB2	0.133	0.62	0.242	0.37	0.477	0.001	0.462	0.07
RHOA	0.693	0.003	0.324	0.22	−0.056	0.84	0.171	0.53
RHOB	−0.094	0.73	0.041	0.88	0.559	0.02	0.201	0.45
Cell proliferation and migration (n = 3)
Ki67	0.277	0.3	−0.135	0.61	−0.665	0.006	−0.381	0.1
MMP2	0.121	0.65	0.118	0.66	0.800	<0.0001	0.335	0.2
MMP9	0.139	0.61	0.041	0.88	0.185	0.49	0.07	0.8
Immunity (n = 5)
IDO1	0.272	0.3	−0.025	0.94	−0.727	0.001	−0.601	0.014
TDO2	0.046	0.87	0.103	0.7	0.218	0.41	0.163	0.54
PD1	−0.155	0.56	−0.132	0.62	0.056	0.84	−0.261	0.25
CD274	0.199	0.46	0.156	0.56	−0.251	0.34	−0.332	0.15
PDL2	−0.015	0.95	−0.172	0.517	0.455	0.08	−0.032	0.76
Angiogenesis (n = 6)
FLT1	−0.407	0.12	−0.394	0.13	0.032	0.91	−0.176	0.51
VEGF165	−0.531	0.03	−0.641	0.01	−0.321	0.23	−0.013	0.68
VEGF189	−0.181	0.51	−0.238	0.37	−0.156	0.56	−0.046	0.86
KDR	−0.081	0.77	−0.079	0.77	0.482	0.06	0.061	0.82
VEGFC	0.01	0.88	0.132	0.63	0.788	0.0001	0.353	0.18
NRP1	0.131	0.62	0.168	0.53	0.838	<0.0001	0.324	0.22

r, Spearman’s rank test (relationship between two quantitative parameters). Values in bold type are statistically significant at confidence level greater than 99% (p value < 0.01) and r > 0.6. CYP1B1 and AhRR were not significantly increased in intestinal GC and statistical correlations should be considered with caution (see Table 2). x, maximum correlation = 1.