Table 1.
Serum levels of heart and liver enzymes, platelet counts and prothrombin ratio at the end of all six experiments.
| Experiment | #16956 | #16935 | #16950 | #17353 | #17012 | #17020 | Reference * |
|---|---|---|---|---|---|---|---|
| Bilirubin [mg/dL] | <0.1 | <0.1 | 5.8 | 5.8 | <0.1 | <0.1 | ≤1.2 |
| AST [U/L] | 27 | 64 | 1360 | 332 | 56 | 456 | ≤49 |
| PR [%] | 88 | 128 | 13 | 41 | 141 | 60 | 70–130 |
| CHE [kU/L] | 112 | 13.4 | 1.2 | 1.9 | 1.6 | 8.6 | 4.6–11.5 |
| Trop. T [ng/mL] | <0.013 | <0.013 | 10.30 | 4.85 | 0.043 | 0.373 | ≤0.014 |
| CK total [U/L] | 47 | 79 | 18689 | 5826 | 116 | 501 | ≤189 |
| LDH [U/L] | 361 | 757 | 13630 | 1028 | 729 | 2429 | ≤249 |
| Platelets [G/L] | 498 | 498 | 367 | 42 | 118 | 386 | 150–300 |
| Survival [days] | 90 | 90 | 1 | 1 | 120 | 170 | |
| Causes for euthanasia | Study endpoint |
Study endpoint |
Technical failure
(pulmonary stenosis) |
Technical failure
(insufficient perfusion) |
Recalcitrant pleural effusions |
Graft failure (humoral rejection) |
AST, aspartate aminotransferase; CHE, cholinesterase; Trop. T, troponin T; CK, creatine kinase; LDH, lactate dehydrogenase; PR, prothrombin ratio. The two experiments #16950 and #17353 were excluded from further data analysis as they had to be stopped within the first 24 h due to technical failures. *, Reference values as defined by the Institute of Laboratory Medicine (University Hospital, LMU Munich, Munich, Germany).