Table 3.
Adjusted Association between Baseline Quantitative CT Features and Clinically Relevant Outcomes in the Pooled Prospective Observation of Fibrosis in the Lung Clinical Endpoints Cohort (n = 426)
| CT Measure | n | Two-Year Progression-Free Survival |
Five-Year Survival |
||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | ||
| Lung volume | 427 | 0.98 | 0.96–0.99 | 0.001 | 0.98 | 0.97–0.99 | 0.007 |
| Airway volume | 415 | 1.45 | 0.43–4.85 | 0.545 | 3.74 | 1.28–10.92 | 0.016 |
| Vascular volume | 426 | 1.30 | 1.12–1.51 | 0.001 | 1.37 | 1.20–1.57 | <0.001 |
| Fibrosis volume | 427 | 1.17 | 1.12–1.22 | <0.001 | 1.17 | 1.12–1.22 | <0.001 |
Definition of abbreviations: CI = confidence interval; CT = computed tomography; HR = hazard ratio.
Model adjusted for gender, age, and physiology stage at the time of CT. HRs are per 0.1-L change in high-resolution CT biomarker volume.