Figure 7.

DHA’s role in reducing oxidative stress within cardiomyocytes. DHA plays a role in alleviating oxidative stress within cardiomyocytes. DHA increases the promotion of cardiolipin within the mitochondrial membrane, which subsequently reduces mitochondrial stress and subsequent dysfunction due to oxidative damage. DHA also attenuates the Nrkb pathway and reduces the production of inflammatory cytokines and activation of genes such as appa, Myrh7, and Agtr-alpha, which have been implicated in hypertrophy and fibrosis of cardiomyocytes. DHA also enhances eNOS activity through AKT and HSP90 activation, which subsequently enhances nitric oxide production and minimizes oxidative stress.