Figure 3.

(A) In the first panel, the MW indices were evaluated before TEER. (B) In the second panel, the MW indices were evaluated six months after TEER. In this case, an impairment of strain and all myocardial indices can be seen (except GWW) after TEER due to an acute reduction in the LV preload. GWI is defined as the total work within the area of the LV pressure–strain loop (area circled in red); GCW is the MW during segmental shortening in the systole and segmental lengthening during the isovolumic relaxation time; GWW is the work performed during lengthening in the systole and shortening during isovolumic relaxation; GWE is the ratio between the GCW divided by the sum of the GCW and GWW [15,16]. MW, myocardial work; GLS, global longitudinal strain; GWI, global work index; GCW, global constructive work; GWW, global wasted work; GWE, global work efficiency; BP, blood pressure.