Table 3.

Echocardiographic changes after TEER (median follow-up 6 months, IQR: 3 to 9 months). Significant p-values are in bold. LA, left atrial; LVEF, left ventricular ejection fraction; LVED, left ventricular end-diastolic volume; LVESV, left ventricular end-systolic volume; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; LV GLS, left ventricular global longitudinal strain; GWI, global work index; GCW, global constructive work; GWW, global wasted work; GWE, global work efficiency; LA, left atrial; TAPSE, tricuspid annular plane systolic excursion; RV FWS, right ventricular free wall longitudinal strain; PASP, pulmonary artery systolic pressure. (*) The first 16 variables were expressed as the means and standard deviations (**) Cut-offs according to the 2022 ESC Guidelines for the diagnosis and treatment of pulmonary hypertension [19].

	All Patients One Month before TEER (*)	All Patients Six Months after TEER (*)	p-Value
LVEF (%)	47.37 ± 14.26	43.74 ± 15.38	<0.001
LVEDV (mL)	130.59 ± 56.11	123.00 ± 53.24	0.049
LVESV (mL)	72.60 ± 47.17	71.33 ± 44.69	0.584
LVEDD (mm)	54.81 ± 8.96	53.30 ± 9.30	0.013
LVESD (mm)	40.09 ± 11.34	39.83 ± 11.57	0.742
GLS (%)	−13.28 ± 3.82	−12.28 ± 3.97	0.085
GWI (mmHg%)	1292.52 ± 608.54	1113.89 ± 489.49	0.001
GCW (mmHg%)	1647.15 ± 686.32	1438.56 ± 559.95	0.009
GWW (mmHg%)	173.50 ± 126.75	202.84 ± 104.63	0.062
GWE (mmHg%)	87.48 ± 8.18	85.11 ± 7.73	0.007
LA volume (mL)	70.52 ± 34.10	70.04 ± 36.62	0.841
LA strain reservoir (%)	12.03 ± 6.38	10.00 ± 4.56	0.002
TAPSE (mm)	17.80 ± 3.90	17.97 ± 3.96	0.687
RV FWS (%)	−19.36 ± 5.84	−20.01 ± 5.66	0.477
PASP (mmHg)	53.64 ± 18.64	43.86 ± 14.92	<0.001
TAPSE/PASP	0.39 ± 0.19	0.45 ± 0.18	0.021
TAPSE/PASP < 0.32 (**)	30 (38.46%)	13 (16.66%)	0.006
PASP > 56 mmHg	33 (42.30%)	16 (20.51%)	0.006
PASP > 40 mmHg	57 (73.07%)	46 (58.97%)	0.052