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. 2024 Aug 1;12(8):1726. doi: 10.3390/biomedicines12081726

Figure 2.

Figure 2

Injection of AAV-L1 reduces the loss of hippocampal NeuN-positive granule neurons in the dentate gyrus of APP/PS1 mice. (A,C,E) Representative images of NeuN-immunostained (NeuN+) neurons in the CA1 (A), CA3 (C), and DG (E) subfields of the hippocampus. Or—stratum oriens, pyr—stratum pyramidale, rad—stratum radiatum, gr—stratum granulosum, hil—hilus of the dentate gyrus. Scale bar: 50 µm. (B,D,F) Densities of the hippocampal NeuN-positive neurons in the pyramidal layer of the CA1 (B), CA3 (D), and granule cells in the DG (F) in wild-type (WT), AAV-L1, and AAV-GFP-injected APP/PS1 mice. Data are shown as mean + standard deviation. Asterisks indicate the differences between treatments, while the hashtag indicates a difference from the wild-type control; one-way ANOVA with Holm–Sidak post hoc, p < 0.05; n = 5 mice/group.