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. 2024 Aug 1;12(8):1726. doi: 10.3390/biomedicines12081726

Figure 4.

Figure 4

The loss of perisomatic inhibitory synapses on principal neuron cell bodies in the hippocampus of APP/PS1 mice is reduced by AAV-L1 injection. (A,C,E) Representative confocal micrographs of VGAT-(red) and parvalbumin (PV, green)-immunostained perisomatic terminals around CA1 (A), CA3 (C), pyramidal neurons (pyr) and DG granule cells (gr) (E). Scale bar: 10 µm. (B,D,F) Diagrams represent the number of parvalbumin-positive/VGAT-positive (PV+) and parvalbumin-negative/VGAT-positive (PV-) perisomatic terminals per unit length (mm) in the CA1 (B), CA3 (D), and DG (F) of wild-type (WT) mice, and APP/PS1 mice injected with either AAV-L1 or AAV-GFP. Data are shown as mean + SD. Asterisks indicate a difference between the injections (AAV-L1 or AAV-GFP), hashtags indicate a difference between APP/PS1 mice and the wild-type control, in a two-way ANOVA with the factors “parvalbumin expression” and “viral injection”, followed by the Holm–Sidak post hoc method, p < 0.05; n = 5 mice/group.