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. 2024 Aug 5;12(8):1758. doi: 10.3390/biomedicines12081758

Figure 2.

Figure 2

Schematic representation of choroidal melanoma tumor microenvironment, tumor-derived extracellular vesicles, and circulating hybrid cells on pathogenesis. Choroidal melanomas are characterized by central angiogenesis and peripheral tumor cell growth. They secrete LAG-3, galectin-3, and tumor-derived extracellular vesicles (TEVs). LAG-3 and galectin-3 inhibit T cell activation and cancer cell apoptosis respectively. TEVs promote choroidal melanoma proliferation, migration, and invasion. The figure was created with BioRender.com.